The Molecular Evolutionary Genetics Analysis (MEGA) software was developed with the goal of providing a biologist centric, integrated suite of tools for statistical analyses of DNA and protein sequence data from an evolutionary standpoint. It is available free of charge from Introduction This version of MEGA is intended for the Windows platform, and it has been configured for effective use on Mac OS X and Linux desktops.
The MEGA user interface has now been enhanced to be activity driven to make it easier for the use of both beginners and experienced scientists. In computer simulation analyses, ML tree inference algorithms in MEGA5 compared favorably with other software packages in terms of computational efficiency and the accuracy of the estimates of phylogenetic trees, substitution parameters, and rate variation among sites. The newest addition in MEGA5 is a collection of maximum likelihood (ML) analyses for inferring evolutionary trees, selecting best-fit substitution models (nucleotide or amino acid), inferring ancestral states and sequences (along with probabilities), and estimating evolutionary rates site-by-site.
Here, we announce the release of Molecular Evolutionary Genetics Analysis version 5 (MEGA5), which is a user-friendly software for mining online databases, building sequence alignments and phylogenetic trees, and using methods of evolutionary bioinformatics in basic biology, biomedicine, and evolution. Comparative analysis of molecular sequence data is essential for reconstructing the evolutionary histories of species and inferring the nature and extent of selective forces shaping the evolution of genes and species.
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